| sedmihodinovýseven-hourAdjective | Adjective |
| sedmnáctseventeenNumber | Number |
| sedmýseventhNumber | Number |
| sednout sito sit downVerb | Verb |
| sehnatto get, find, or obtainVerb | Verb |
| sejítto go down or come downVerb | Verb |
| sejít seto meet upVerb | Verb |
| sekretářkasecretaryNoun | Noun |
| sekundasecondNoun | Noun |
| selfieselfieNoun | Noun |
| semhere, to hereAdverb | Adverb |
| semafortraffic lightNoun | Noun |
| seminářseminarNoun | Noun |
| sendreamNoun | Noun |
| SenátsenátSenateNoun | Noun |
| senátorsenatorNoun | Noun |
| senátorkafemale senatorNoun | Noun |
| seniorseniorNoun | Noun |
| seniorkafemale seniorNoun | Noun |
| senzitivnísensitiveAdjective | Adjective |
| seriálseriesNoun | Noun |
| serverserverNoun | Noun |
| servírkawaitressNoun | Noun |
| servisserviceNoun | Noun |
| sestrasister; nurseNoun | Noun |
| sestřenicefemale cousinNoun | Noun |
| sestřičkanurseNoun | Noun |
| sešitnotebookNoun | Noun |
| setkánímeetingNoun | Noun |
| severnorthNoun | Noun |
| severnínorthernAdjective | Adjective |
| sexsexNoun | Noun |
| sexuálnísexualAdjective | Adjective |
| sexysexyAdjective | Adjective |
| seznamlistNoun | Noun |
| seznámenífirst meeting; introductionNoun | Noun |
| seznámit seto meet or get to knowVerb | Verb |
| seznamovat seto meet or get to knowVerb | Verb |
| scházet seto meet up regularlyVerb | Verb |
| Schengenský prostorschengenský prostorSchengen AreaWord combination | Word combination |
| schodstepNoun | Noun |
| schodištěstaircaseNoun | Noun |
| schopnostabilityNoun | Noun |
| schopnýcapableAdjective | Adjective |
| schovávatto hide, to put awayVerb | Verb |
| schránkaclipboardNoun | Noun |
| schůzemeetingNoun | Noun |
| schůzkameeting; appointmentNoun | Noun |
| schvalovatto approveVerb | Verb |
| sídlištěhousing estateNoun | Noun |
| sídloregistered office; seatNoun | Noun |
| silněstrongly, heavilyAdverb | Adverb |
| silniceroadNoun | Noun |
| silničníroadAdjective | Adjective |
| silnýstrongAdjective | Adjective |
| SilvestrsilvestrNew Year's EveNoun | Noun |
| sirupsyrupNoun | Noun |
| síťnetworkNoun | Noun |
| situacesituationNoun | Noun |
| sjetto go or ride downVerb | Verb |
| skálarockNoun | Noun |
| skandálscandalNoun | Noun |
| skenovatto scanVerb | Verb |
| skládatto put together, fold, or composeVerb | Verb |
| skladatelcomposerNoun | Noun |
| skleněnýglassAdjective | Adjective |
| skleniceglassNoun | Noun |
| skleničkasmall glassNoun | Noun |
| sklepcellarNoun | Noun |
| sklípekwine cellarNoun | Noun |
| skloglassNoun | Noun |
| skončitto finish, end, or end upVerb | Verb |
| skopové masomuttonWord combination | Word combination |
| skoroalmost, nearlyAdverb | Adverb |
| skříňwardrobeNoun | Noun |
| skřivanskylarkNoun | Noun |
| skřiváneksmall skylarkNoun | Noun |
| skupinagroup, bandNoun | Noun |
| skupinovýgroupAdjective | Adjective |
| skutečnostfact; realityNoun | Noun |
| skutečnýrealAdjective | Adjective |
| skvěleexcellently, greatAdverb | Adverb |
| skvělýgreatAdjective | Adjective |
| skypeSkypeNoun | Noun |
| skypovánískypingNoun | Noun |
| skypovatto Skype or video callVerb | Verb |
| slabýweakAdjective | Adjective |
| sládekbrewerNoun | Noun |
| sladkýsweetAdjective | Adjective |
| slaninabaconNoun | Noun |
| slanýsaltyAdjective | Adjective |
| slavitto celebrateVerb | Verb |
| slavnýfamousAdjective | Adjective |
| slečnaMiss, young womanNoun | Noun |
| sledovatto watch, follow, or observeVerb | Verb |
| slepicehenNoun | Noun |
| slepýblindAdjective | Adjective |
| slevadiscountNoun | Noun |
| SlezskoslezskoSilesiaNoun | Noun |
| slezskýSilesianAdjective | Adjective |