| safarisafariNoun | Noun |
| sahatto touch or reach towardVerb | Verb |
| sakojacketNoun | Noun |
| sálhallNoun | Noun |
| salámsalamiNoun | Noun |
| salátsaladNoun | Noun |
| sámalonePronoun | Pronoun |
| sametovývelvetAdjective | Adjective |
| samostatnostautonomy; independenceNoun | Noun |
| samostatnýseparate, independentAdjective | Adjective |
| samozřejměof courseAdverb | Adverb |
| samýnothing but; allAdjective | Adjective |
| sanitkaambulanceNoun | Noun |
| sáňkovatto sledVerb | Verb |
| sbíratto collect or gatherVerb | Verb |
| sborchoirNoun | Noun |
| scénáristascreenwriterNoun | Noun |
| scénářscreenplayNoun | Noun |
| sci-fiscience fictionNoun | Noun |
| sebekritickýself-criticalAdjective | Adjective |
| sebevědomíself-confidence; self-esteemNoun | Noun |
| sebevraždasuicideNoun | Noun |
| secondhandsecondhand shopNoun | Noun |
| sedačkasofaNoun | Noun |
| sedadloseatNoun | Noun |
| sedat sito sit down repeatedly or habituallyVerb | Verb |
| sedětto sitVerb | Verb |
| sedět (na židli)to sitVerb | Verb |
| sedět (o oblečení)to fit, especially clothesVerb | Verb |
| sedmsevenNumber | Number |
| sedmdesátseventyNumber | Number |
| sedmdesátýseventiethNumber | Number |
| sedmihodinovýseven-hourAdjective | Adjective |
| sedmnáctseventeenNumber | Number |
| sedmýseventhNumber | Number |
| sednout sito sit downVerb | Verb |
| sehnatto get, find, or obtainVerb | Verb |
| sejítto go down or come downVerb | Verb |
| sejít seto meet upVerb | Verb |
| sekretářkasecretaryNoun | Noun |
| sekundasecondNoun | Noun |
| selfieselfieNoun | Noun |
| semhere, to hereAdverb | Adverb |
| semafortraffic lightNoun | Noun |
| seminářseminarNoun | Noun |
| sendreamNoun | Noun |
| SenátsenátSenateNoun | Noun |
| senátorsenatorNoun | Noun |
| senátorkafemale senatorNoun | Noun |
| seniorseniorNoun | Noun |
| seniorkafemale seniorNoun | Noun |
| senzitivnísensitiveAdjective | Adjective |
| seriálseriesNoun | Noun |
| serverserverNoun | Noun |
| servírkawaitressNoun | Noun |
| servisserviceNoun | Noun |
| sestrasister; nurseNoun | Noun |
| sestřenicefemale cousinNoun | Noun |
| sestřičkanurseNoun | Noun |
| sešitnotebookNoun | Noun |
| setkánímeetingNoun | Noun |
| severnorthNoun | Noun |
| severnínorthernAdjective | Adjective |
| sexsexNoun | Noun |
| sexuálnísexualAdjective | Adjective |
| sexysexyAdjective | Adjective |
| seznamlistNoun | Noun |
| seznámenífirst meeting; introductionNoun | Noun |
| seznámit seto meet or get to knowVerb | Verb |
| seznamovat seto meet or get to knowVerb | Verb |
| scházet seto meet up regularlyVerb | Verb |
| schodstepNoun | Noun |
| schodištěstaircaseNoun | Noun |
| schopnostabilityNoun | Noun |
| schopnýcapableAdjective | Adjective |
| schovávatto hide, to put awayVerb | Verb |
| schránkaclipboardNoun | Noun |
| schůzemeetingNoun | Noun |
| schůzkameeting; appointmentNoun | Noun |
| schvalovatto approveVerb | Verb |
| sídlištěhousing estateNoun | Noun |
| sídloregistered office; seatNoun | Noun |
| silněstrongly, heavilyAdverb | Adverb |
| silniceroadNoun | Noun |
| silničníroadAdjective | Adjective |
| silnýstrongAdjective | Adjective |
| SilvestrsilvestrNew Year's EveNoun | Noun |
| sirupsyrupNoun | Noun |
| síťnetworkNoun | Noun |
| situacesituationNoun | Noun |
| sjetto go or ride downVerb | Verb |
| skálarockNoun | Noun |
| skandálscandalNoun | Noun |
| skenovatto scanVerb | Verb |
| skládatto put together, fold, or composeVerb | Verb |
| skladatelcomposerNoun | Noun |
| skleněnýglassAdjective | Adjective |
| skleniceglassNoun | Noun |
| skleničkasmall glassNoun | Noun |
| sklepcellarNoun | Noun |