| sklípekwine cellarNoun | Noun |
| skloglassNoun | Noun |
| skončitto finish, end, or end upVerb | Verb |
| skoroalmost, nearlyAdverb | Adverb |
| skříňwardrobeNoun | Noun |
| skřivanskylarkNoun | Noun |
| skřiváneksmall skylarkNoun | Noun |
| skupinagroup, bandNoun | Noun |
| skupinovýgroupAdjective | Adjective |
| skutečnostfact; realityNoun | Noun |
| skutečnýrealAdjective | Adjective |
| skvěleexcellently, greatAdverb | Adverb |
| skvělýgreatAdjective | Adjective |
| skypeSkypeNoun | Noun |
| skypovánískypingNoun | Noun |
| skypovatto Skype or video callVerb | Verb |
| slabýweakAdjective | Adjective |
| sládekbrewerNoun | Noun |
| sladkýsweetAdjective | Adjective |
| slaninabaconNoun | Noun |
| slanýsaltyAdjective | Adjective |
| slavitto celebrateVerb | Verb |
| slavnýfamousAdjective | Adjective |
| slečnaMiss, young womanNoun | Noun |
| sledovatto watch, follow, or observeVerb | Verb |
| slepicehenNoun | Noun |
| slepýblindAdjective | Adjective |
| slevadiscountNoun | Noun |
| SlezskoslezskoSilesiaNoun | Noun |
| slezskýSilesianAdjective | Adjective |
| slíbitto promiseVerb | Verb |
| slibovatto promiseVerb | Verb |
| slonelephantNoun | Noun |
| sloupcolumn, poleNoun | Noun |
| SlovákslovákSlovak manNoun | Noun |
| slovanskýSlavic, SlavonicAdjective | Adjective |
| SlovenkaslovenkaSlovak womanNoun | Noun |
| SlovenskoslovenskoSlovakiaNoun | Noun |
| slovenskyin SlovakAdverb | Adverb |
| slovenštinaSlovak languageNoun | Noun |
| slovesoverbNoun | Noun |
| slovíčkolittle wordNoun | Noun |
| slovníword-relatedAdjective | Adjective |
| slovníkdictionaryNoun | Noun |
| slovowordNoun | Noun |
| složenkapayment slipNoun | Noun |
| složitto composeVerb | Verb |
| sluchhearingNoun | Noun |
| sluchátkoearpiece, handsetNoun | Noun |
| sluncesunNoun | Noun |
| slunečnísolar; sun-relatedAdjective | Adjective |
| slunečnosunnyAdverb | Adverb |
| slušetto suit, to look good onVerb | Verb |
| službaserviceNoun | Noun |
| službyservicesNoun | Noun |
| slyšetto hearVerb | Verb |
| smartphonesmartphoneNoun | Noun |
| smát selaughVerb | Verb |
| smazatto delete, to eraseVerb | Verb |
| smaženýfriedAdjective | Adjective |
| smažitto fryVerb | Verb |
| směnashiftNoun | Noun |
| směnárnaexchange officeNoun | Noun |
| směrdirectionNoun | Noun |
| smětto be allowed to, mayVerb | Verb |
| smetanacreamNoun | Noun |
| smíchatto mixVerb | Verb |
| smlouvacontractNoun | Noun |
| smrdětto stink, to smell badVerb | Verb |
| smrtdeathNoun | Noun |
| smůlabad luckNoun | Noun |
| smutněsadlyAdverb | Adverb |
| smutnýsadAdjective | Adjective |
| smyslsense, meaningNoun | Noun |
| snadperhaps, hopefullyAdverb | Adverb |
| snadnoeasilyAdverb | Adverb |
| snadnýeasyAdjective | Adjective |
| snachadaughter-in-lawNoun | Noun |
| snášetto tolerate, to bearVerb | Verb |
| sňatekmarriageNoun | Noun |
| snažit setryVerb | Verb |
| sněmovnaChamber of DeputiesNoun | Noun |
| sněženísnowfallNoun | Noun |
| sněžitto snowVerb | Verb |
| snídaněbreakfastNoun | Noun |
| snídathave breakfastVerb | Verb |
| sníhsnowNoun | Noun |
| snístto eat up, to finish eatingVerb | Verb |
| snítto dreamVerb | Verb |
| sníženýreducedAdjective | Adjective |
| sobeckýselfishAdjective | Adjective |
| sobotaSaturdayNoun | Noun |
| socialismussocialismNoun | Noun |
| socialistickýsocialistAdjective | Adjective |
| sociálnísocialAdjective | Adjective |
| softwaresoftwareNoun | Noun |
| sochastatueNoun | Noun |
| sochařsculptorNoun | Noun |
| sochařkafemale sculptorNoun | Noun |
| solárnísolarAdjective | Adjective |